A Label-free Optical Biosensor for Onsite COVID-19 Detection
EMBS Academy. Rong G. 07/20/20; 307075; 2573
Guoguang Rong
Guoguang Rong
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Nbr: 2573
Author: Rong, Guoguang
Co-Authors: Rong, Guoguang; Bian, Sumin; Liu, Xinxin; Su, Yi; Sawan, Mohamad
Affiliation: Westlake University

Session Title: COVID-19 Wearable Devices, Biosensors and mHealth for Monitoring COVID

This work demonstrates a label-free optical biosensor for rapid onsite detection of COVID-19 virus. Nanoporous silicon Distributed Bragg Reflector (DBR) and Localized Surface Plasmon Resonance (LSPR) were combined to construct a high sensitivity biosensor. Porous silicon DBR can be designed to have nearly total reflection in the visible range. After coating DBR with noble metal, LSPR can be excited and even enhanced by DBR inside its reflection band. The peak and valley in the reflection spectrum of the resulting device is very sensitive to any biological binding on metal surface, which manifests itself as spectral red shifts in the reflection spectrum collected by portable fiber spectrometer. We demonstrate the sensitivity of the DBR LSPR biosensor for non-specific detection of liquids of varying refractive indices. Results show that the sensitivity can reach 375 nm/RIU(Refractive Index Unit). Clinical Relevance—This work establishes the structural design, fabrication and operation principle of the label-free nanoporous silicon DBR LSPR optical biosensor.

Keywords:
Nbr: 2573
Author: Rong, Guoguang
Co-Authors: Rong, Guoguang; Bian, Sumin; Liu, Xinxin; Su, Yi; Sawan, Mohamad
Affiliation: Westlake University

Session Title: COVID-19 Wearable Devices, Biosensors and mHealth for Monitoring COVID

This work demonstrates a label-free optical biosensor for rapid onsite detection of COVID-19 virus. Nanoporous silicon Distributed Bragg Reflector (DBR) and Localized Surface Plasmon Resonance (LSPR) were combined to construct a high sensitivity biosensor. Porous silicon DBR can be designed to have nearly total reflection in the visible range. After coating DBR with noble metal, LSPR can be excited and even enhanced by DBR inside its reflection band. The peak and valley in the reflection spectrum of the resulting device is very sensitive to any biological binding on metal surface, which manifests itself as spectral red shifts in the reflection spectrum collected by portable fiber spectrometer. We demonstrate the sensitivity of the DBR LSPR biosensor for non-specific detection of liquids of varying refractive indices. Results show that the sensitivity can reach 375 nm/RIU(Refractive Index Unit). Clinical Relevance—This work establishes the structural design, fabrication and operation principle of the label-free nanoporous silicon DBR LSPR optical biosensor.

Keywords:
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